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KMID : 0613820070170111505
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Journal of Life Science
2007 Volume.17 No. 11 p.1505 ~ p.1510
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Investigation of Single Nucleotide Polymorphisms in the Adipocyte Fatty-Acid Binding Protein (FABP4) Gene
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Kim Sang-Wook
Jung Ji-Hye
Kim Kwan-Suk
Lee Cheol-Koo
Kim Jong-Joo
Choi Bong-Hwan
Kim Tae-Hun
Song Ki-Duk
Cho Byung-Wook
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Abstract
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We found 8 single nucleotide polymorphisms (SNPs) in adipocyte fatty acid bonding protein (FABP4) gene as candidate gene of FAT1 locus on pig chromosome 4. With over 800 heads of major commercial pig breeds including Duroc, Landrace, Berkshire and Yorkshire, we analyzed SNPs of FABP4 gene to determine possible effects of FABP4 genotype to economically important traits. 400~800 bp amplicons in FABP4 gene were used PCR-RFLP for each SNPs and we found that the frequency of some SNPs of this gene was different among the breeds. According to the statistical analyses to determine possible associations of each genotype with economic traits, it was found that subgroup with different genotypes showed significant differences in daily gain, backfat thickness, lean percentage and feed conversion ratio (P<0.05). Thus, as a part of enhancing the selection competence related to swine growth rate and lean percentage, it is expected that FABP4 gene markers verified in this study will be useful to use for Korean commercial pig industry.
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KEYWORD
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Economic traits, swine, SNP Detection, PCR-RFLP, polymorphism, FABP
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